发明名称 |
Adeno-associated virus mediated B7.1 vaccination synergizes with angiostatin to eradicate disseminated liver metastatic cancers |
摘要 |
The present invention provides adeno-associated viral (AAV) vectors encoding an angiostatin protein ("AAV-angiostatin vector") and/or a costimulatory molecule B7.1 ("AAV-B7.1 vector"). The AAV-angiostatin vector can be administered to a subject, alone or in combination, sequentially or simultaneously, with a AAV-B7.1 vector for treatment, management or prevention of metastatic tumors. Pharmaceutical compositions and vaccines comprising the AAV-angiostatin vector and/or the AAV-B7.1 vector and methods of manufacturing are also described. Administration of AAV-angiostatin and AAV-B7.1 vectors by intraportal and muscular injections are also provided.
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申请公布号 |
US2004156828(A1) |
申请公布日期 |
2004.08.12 |
申请号 |
US20040753164 |
申请日期 |
2004.01.07 |
申请人 |
XU RUIAN;SUN XUEYING;FAN SHEUNG-TAT;KUNG HSIANG-FU;KRISSANSEN GEOFFREY;FUNG PETER CHIN WAN |
发明人 |
XU RUIAN;SUN XUEYING;FAN SHEUNG-TAT;KUNG HSIANG-FU;KRISSANSEN GEOFFREY;FUNG PETER CHIN WAN |
分类号 |
A61K48/00;C07K14/74;C12N9/68;C12N15/861;C12N15/864;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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