RECOMBINANT HEPATITIS A VIRUS ANTIGENS OBTAINED IN PLANT CELLS

摘要

The invention relates to recombinant hepatitis A virus antigens obtained in plant cells. More specifically, the invention relates to the generation of genetic constructions based on modified fragments of the genome of hepatitis A virus (HAV), using strain M2 which has been isolated in Cuba. The nucleotide sequences of said fragments fused with suitable positioning and regulation signals are expressed in transgenic plants, giving rise to recombinant HAV antigens comprising pentamers and/or empty coats, which can generate an immune response.