发明名称 |
MUCOSAL MENINGOCOCCAL VACCINES |
摘要 |
The invention provides immunogenic compositions for mucosal delivery comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of N. meningitidis. It is preferred that the capsular saccharides in the compositions of the invention are conjugated to carrier protein(s) and/or are oligosaccharides. Conjugated oligosaccharide antigens are particularly preferred. The invention also provides immunogenic compositions comprising (a) a capsular saccharide antigen from serogroup C of N. meningitidis, and (b) a chitosan adjuvant. The composition preferably comprises (c) one or more further antigens and/or (d) one or more further adjuvants. The compositions are particularly suitable for mucosal delivery, including intranasal delivery. The use of chitosan and/or detoxified ADP-ribosylating toxin adjuvants enhances anti-meningococcal mucosal immune responses and can shift the Th1/Th2 bias of the responses. |
申请公布号 |
CA2514330(A1) |
申请公布日期 |
2004.08.12 |
申请号 |
CA20042514330 |
申请日期 |
2004.01.30 |
申请人 |
CHIRON SRL;UNIVERSITEIT LEIDEN |
发明人 |
BAUDNER, BARBARA;DEL GIUDICE, GIUSEPPE |
分类号 |
A61K39/39;A61K39/02;A61K39/09;A61K39/095;A61K39/102;A61K39/385;A61P31/04 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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