发明名称 |
Trisubstituted carbocyclic cyclophilin binding compounds and their use |
摘要 |
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.
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申请公布号 |
US2004157919(A1) |
申请公布日期 |
2004.08.12 |
申请号 |
US20030713566 |
申请日期 |
2003.11.14 |
申请人 |
WU YONG-QIAN;BELYAKOV SERGEI;HAMILTON GREGORY S.;LIMBURG DAVID;STEINER JOSEPH P.;VAAL MARK;WEI LING;WILKINSON DOUGLAS |
发明人 |
WU YONG-QIAN;BELYAKOV SERGEI;HAMILTON GREGORY S.;LIMBURG DAVID;STEINER JOSEPH P.;VAAL MARK;WEI LING;WILKINSON DOUGLAS |
分类号 |
A61K31/198;A61K31/325;(IPC1-7):A61K31/325 |
主分类号 |
A61K31/198 |
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