Compositions and methods for inhibiting TGF-beta

摘要

This invention provides compounds that are inhibitors of the TGF-beta signaling pathway. The compounds are represented by formula I: where A' is N or CH; Ring B is preferably an triazolyl, imidazolyl, or thiazolyl ring; -X-D- is a linker group; and G is an optionally substituted aryl or heteroaryl ring. The compounds are useful for treating cardiovascular disease.