发明名称 |
NOVEL GLUTAMIC ACID RECEPTOR AND UTILIZATION THEREOF |
摘要 |
An agonist or antagonist of glutamic acid or an allosteric modulator is screened by reacting a glutamic acid receptor protein having the following properties with a substance binding thereto in the presence of a test substance and detecting the inhibition or promotion of the reaction: (A) it has a transmembrane domain and an intracellular domain common to those of type 4 metabotropic glutamic acid receptor protein, or (B) it has an extracellular domain by about 316 or 327 amino acid residues shorter than that of the type 4 metabotropic glutamic acid receptor protein. <IMAGE>
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申请公布号 |
EP1445314(A1) |
申请公布日期 |
2004.08.11 |
申请号 |
EP20020770242 |
申请日期 |
2002.10.23 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
SAN GABRIEL, ANA;MAEKAWA, TAKAMI;UNEYAMA, HISAYUKI;TORII, KUNIO |
分类号 |
A61K38/00;A61P25/00;A61P43/00;C07K14/705;C12N15/12;(IPC1-7):C12N15/12;C12P21/02;A61K45/00;A61P21/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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