发明名称 |
Method of synthesizing 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol |
摘要 |
A method of making 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol. The method includes the steps of condensing a bicyclic ketone with an allylic phosphine oxide to produce a protected 19-nor-pregnacalciferol analog, thereafter cleaving the protecting group to form 22-alcohol, converting the alcohol to an ester, reducing the ester to 17beta-isopropyl-19-nor-vitamin D analog, and finally deprotecting the 17beta-isopropyl derivative to form the desired compound.
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申请公布号 |
US6774251(B2) |
申请公布日期 |
2004.08.10 |
申请号 |
US20030397135 |
申请日期 |
2003.03.26 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA HECTOR F.;GOWLUGARI SUMITHRA;SICINSKI RAFAL R. |
分类号 |
C07C401/00;(IPC1-7):C07C401/00;A61K31/59 |
主分类号 |
C07C401/00 |
代理机构 |
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