发明名称 |
Methods for diagnosing and treating autoimmune disease |
摘要 |
The invention provides a method of detecting autoimmune disease in a mammal, comprising providing a biological sample from a mammal and detecting proteasome activity, wherein a reduction in proteasome activity from a basal state is indicative of autoimmune disease. In addition, the invention encompasses a method of treating an autoimmune disease in a mammal, comprising administering to a mammal suspected of suffering from an autoimmune disease an agent which restores NFkappaB activity in an amount and for a time sufficient to result in normal NFkappaB activity in the mammal.
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申请公布号 |
US6773705(B1) |
申请公布日期 |
2004.08.10 |
申请号 |
US19990258682 |
申请日期 |
1999.02.26 |
申请人 |
GENERAL HOSPITAL CORPORATION |
发明人 |
FAUSTMAN DENISE L.;HAYASHI TAKUMA |
分类号 |
A61K38/00;A61K38/17;A61K38/19;A61K48/00;A61P37/06;C07K14/47;C12N9/12;C12N9/64;C12Q1/37;G01N33/564;(IPC1-7):A61K39/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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