发明名称 Process for the preparation of granular and porous sucralfate dry gel
摘要 Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 mum, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titer of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.
申请公布号 US6773722(B2) 申请公布日期 2004.08.10
申请号 US20030449266 申请日期 2003.05.29
申请人 LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. 发明人 ZAGNOLI GIORGIO;COLOMBO PAOLO;MAGGI LORETTA;CUDAZZO FABRIZIO
分类号 A61K9/00;A61K9/14;A61K9/24;(IPC1-7):A61K9/28 主分类号 A61K9/00
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