发明名称 |
REDUCTION OF SKIN IRRITATION AND RESISTANCE DURING ELECTROTRANSPORT |
摘要 |
An electrotransport delivery device (10) utilizing reservoir (16, 18) buffering at a select pH ranges in order to reduce skin irritation and skin resistance is provided. Cathodic reservoirs are buffered to a pH of less than about 4, preferably to a pH in the range of about 2 to 4, white anodic reservoirs are buffered to a pH above about 4, preferably to a pH in the range of about 4 to 10. Another electrotransport delivery device (10) utilizes a potassium sensor to monitor potassium efflux from the skin. Potassium efflux above a certain predetermined level has been found to be a precursor to skin irritationlerythema. Operation of the device is modified (eg, terminated) when the predetermined potassium efflux level is sensed.
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申请公布号 |
CA2166490(C) |
申请公布日期 |
2004.08.10 |
申请号 |
CA19942166490 |
申请日期 |
1994.08.31 |
申请人 |
ALZA CORPORATION |
发明人 |
CORMIER, MICHEL J.N.;LEDGER, PHILIP W.;JOHNSON, JUANITA;PHIPPS, JOSEPH B.;CHAO, STELLA |
分类号 |
A61N1/30;(IPC1-7):A61N1/30 |
主分类号 |
A61N1/30 |
代理机构 |
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