| 摘要 |
Dimers or oligomers (I) of di-, tri-, tetra- or penta-mers (II) of recombinant fusion proteins (FP) comprising at least one each of components A and B, where A is a biologically active protein (or fragment) and B is a protein (or fragment) that causes dimerization/oligomerization of (I) without requiring a third molecule, is new. Dimers or oligomers (I) of di-, tri-, tetra- or penta-mers (II) of recombinant fusion proteins (FP) comprising at least one each of components A and B, where A is a biologically active protein (or fragment) and B is a protein (or fragment) that causes dimerization/oligomerization of (I) without requiring a third molecule, is new. Particularly A functions as a ligand for antibodies, soluble or membrane-bound signaling molecules or receptors or is an antibody (or its fragment). Independent claims are also included for the following: (a) FP containing as component B a protein of the C1q or collectin families; (b) DNA sequences (II) that encode the FP of (a); (c) expression vectors containing (III); (d) host cells containing the vector of (c); and (e) (II) in which component B of FP is derived from the immunoglobulin, C1q or collectin families of proteins. - ACTIVITY : Antiinflammatory; immunomodulatory; antiapoptotic; apoptotic; antiviral; antibacterial; antimalarial; antiprotozoal; antitumor; endocrinological. No supporting data is given. - MECHANISM OF ACTION : Stimulation of specific immune response; receptor (ant)agonist. |
