摘要 |
The invention relates to heterocyclic aminoalkylpyridine derivatives of the formula I: where R<SUP>1 </SUP>is the radical of a heterocycle having 1 to 3 ring structures, where each ring structure is saturated, unsaturated or aromatic and optionally fused to other ring structures to give a fused ring system and the heterocycle has a total of 1 to 4 N, O and/or S atoms in the ring structures and is optionally monosubstituted, disubstituted or trisubstituted by one or more of the groups -A, -OR<SUP>4</SUP>, -N(R<SUP>4</SUP>)<SUB>2</SUB>, -NO<SUB>2</SUB>, -CN, Hal, -COOR<SUP>4</SUP>, -CON(R<SUP>4</SUP>)<SUB>2</SUB>, -COR<SUP>4</SUP>, -O; R<SUP>2 </SUP>is a phenyl group which is optionally monosubstituted, disubstituted, trisubstituted, tetrasubstituted or pentasubstituted by one or more of the groups Hal, -A, -O-A, -NO<SUB>2 </SUB>or -CN, or is a thienyl group which is optionally monosubstituted or disubstituted by one or more of the groups Hal, -A, -O-A, -NO<SUB>2</SUB>, -CN or thienyl; R<SUP>3 </SUP>is H, -A, -CO-A, -C(R<SUP>4</SUP>)<SUB>2</SUB>R<SUP>2</SUP>, -C(R<SUP>4</SUP>)<SUB>2</SUB>-pyridinediyl-R<SUP>2</SUP>; R<SUP>4 </SUP>is H or -A; A is C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, where 1 to 7 hydrogen atoms are optionally replaced by fluorine; -X- is -O-, -S-, sulfinyl, sulfonyl, -C(R<SUP>4</SUP>)<SUB>2</SUB>-; -Y- is -[C(R<SUP>4</SUP>)<SUB>2</SUB>]<SUB>n</SUB>-; -Z- is -C(R<SUP>4</SUP>)<SUB>2</SUB>-; Hal is F, Cl, Br or I; n is 1, 2, 3 or 4; and their tolerable salts and solvates and their use as medicaments. |