| 摘要 |
PURPOSE: Disubstituted cucurbit£6|urils and a preparing method thereof are provided, thereby easily introducing the substituents into cucurbit£6|urils, so that cucurbit£6|urils can be covalently bound to biochemical compounds, solid surface and solid substrate. CONSTITUTION: The disubstituted cucurbit£6|urils represented by formula (1) is provided, wherein X is O, S or NH; R is selected from optionally substituted C2-C30 alkenyl, optionally substituted C2-C30 alkynyl, optionally substituted C1-C30 alkylcarboxyl, optionally substituted C1-C30 hydroxyalkyl, optionally substituted C1-C30 alkoxy, optionally substituted C1-C30 nitroalkyl, optionally substituted C1-C30 aminoalkyl, optionally substituted C6-C30 aryl, and optionally substituted C6-C30 heteroaryl. The method for preparing disubstituted cucurbit£6|urils of formula (1) comprises reacting disubstituted glycoluril of formula (2) and glycoluril of formula (3) with formaldehyde.
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