A substantially enriched mammalian hematopoietic cell population is provided, which is characterized as a progenitor cell committed to the megakaryocyte lineage. Methods are provided for the isolation and culture of these cells. The cell enrichment methods employ reagents that specifically recognize CD9 and CD41, in conjunction with other markers expressed on lineage committed progenitor cells. These cells give rise exclusively to megakaryocytes and platelets, as evidenced by their growth and differentiation in vitro and in vivo.
申请公布号
WO2004024875(A3)
申请公布日期
2004.08.05
申请号
WO2003US28810
申请日期
2003.09.12
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;NAKORN, THANYAPHONG NA;MIYAMOTO, TOSHIHIRO;WEISSMAN, IRVING, L.
发明人
NAKORN, THANYAPHONG NA;MIYAMOTO, TOSHIHIRO;WEISSMAN, IRVING, L.