| 摘要 |
A multi-layer oral dosage form, preferably a tablet, comprising a matrix cor e comprising a therapeutically effective amount of a first drug (NSAID), where in the matrix core allows sustained release of the first drug; a first layer, which is in contact with the matrix core, comprising a first portion of a pharmaceutically effective amount of a second drug (H2~-blocker antagonist) , wherein the first layer allows sustained release of the second drug; and a second layer, which is in contact with said matrix core, comprising a second portion of the second drug, wherein the second layer allows immediate releas e of the second drug. Methods for preparing the multi-layer dosage form are al so disclosed.
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