IDENTIFICATION OF AN AMPLIFIED GENE AND TARGET FOR DRUG INTERVENTION

摘要

There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the ACK1 gene, which are amplified breast and/or ovarian and/or prostate cancer genes. The ACK1 gene, its expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.