Systems and methods of de-endothelialization

摘要

Apparatus and methods for at least partially de-endothelializing a wall of an aneurysm include an elongate core member including one or more fibers on an outer surface of the core member, the one or more fibers carrying a de-endothelialization agent. The core member is introduced into the aneurysm, thereby releasing the fluid from the one or more fibers within the aneurysm, the fluid disrupting at least a portion of the endothelium of the wall of the aneurysm. Alternatively, the core member includes a coating carrying a de-endothelialization agent, the coating being degradable when exposed to blood to release the de-endothelialization agent.