The invention provides a method for identifying a candidate compound or compounds capable of modulating factors which influence obesity independently of insulin resistance, comprising administering the compound or compounds to a transgenic non-human SLOB animal expressing, as a result of transgene expression, a 5'OT-EST polypeptide or mutant 5'OT-EST polypeptide.
申请公布号
WO2004064714(A2)
申请公布日期
2004.08.05
申请号
WO2004GB00168
申请日期
2004.01.20
申请人
MEDICAL RESEARCH COUNCIL;ROBINSON, IAIN;LETISSIER, PAUL;BAINS, RANDIP;STROM, MOLLY
