MODIFIED OLIGONUCLEOTIDES FOR USE IN GENE MODULATION
摘要
The present invention provides modified oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds are each prepared having a 5'-phosphate precursor which can be modulated to provide a 5'-phosphate group under selected conditions. In another embodiment of the invention the 5'-phosphate precursor is labile inside a target cell thereby providing an oligomeric compounds having a 5'-phosphate intercellularly.
申请公布号
WO2004065579(A2)
申请公布日期
2004.08.05
申请号
WO2004US00927
申请日期
2004.01.14
申请人
ISIS PHARMACEUTICALS, INC.;BOSWELL, HERB;WARD, DONNA, T.;ANDREWS, ROBERT, S.