FLUOROIMIDAZOPYRIMIDINES AS GABA-A ALPHA 2/3 LIGANDS FOR DEPRESSION/ANXIETY

摘要

The present invention provides a compound formula (I), or a pharmaceutically acceptable salt thereof: wherein W is phenyl or pyridyl; X<1> represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X<2> represents hydrogen or halogen; Y represents a chemical bond, an -NH- linkage or a group -OCnH2n-; Z represents an optionally substituted aryl or heteroaryl group; R<1> represents hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, -OR<a>, -SR<a>, -SOR<a>, -SO2R<a>, -SO2NR<a>R<b>, NR<a>R<b>, -NR<a>COR<b>, -NR<a>CO2R<b>, -COR<a>, -CO2R<a>, -CONR<a>R<b> or Cr<a>=NOR<b>; R<a> and R<b> independently represent hydrogen, hydrocarbon or a heterocyclic group; and n is zero, one, two or three; pharmaceutical compositions comprising it; its use in methods of treatment; use of it in the manufacture of medicaments to treat anxiety and/or depression; and methods of treatment for anxiety and/or depression using it.