发明名称 |
MESECNHYMAL STEM CELLS AS A VEHICLE FOR ION CHANNEL TRANSFER IN SYNCYTIAL STRUCTURES |
摘要 |
This invention provides a composition for delivery of a gene to a syncytial structure comprising stem cells incorporated with the gene. This invention also provides a composition for ion channel transfer which comprises stem cells incorporated with a compound in an amount sufficient to create ion channels. This invention also provides for a method of expressing a functional gene product in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a gene, to the syncytial structure. This invention further provides a method of expressing a functional ion channel in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a compound in an amount sufficient to create ion channels, to the syncytial structure. This invention also provides a composition for delivery of small molecules comprising stem cells incorporated with the small molecules or genes encoding the small molecules. |
申请公布号 |
WO2004065580(A2) |
申请公布日期 |
2004.08.05 |
申请号 |
WO2004US00950 |
申请日期 |
2004.01.14 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK;THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEWYORK |
发明人 |
ROSEN, MICHAEL, R.;ROBINSON, RICHARD, B.;COHEN, IRA, S.;BRINK, PETER |
分类号 |
A61K48/00;C07K14/705;C12N5/0775 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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