发明名称 |
RADIOLABELED SELECTIVE ANDROGEN RECEPTOR MODULATORS AND THEIR USE IN PROSTATE CANCER IMAGING AND THERAPY |
摘要 |
Provided is a class of radiolabeled androgen receptor targeting agents (ARTA), useful for prostate cancer imaging and n treating or preventing prostate cancer. The agents define a new subclass of radiolabeled compounds, which are selective androgen receptor modulators (SARM), which demonstrate antiandrogenic activity of a nonsteroidal ligand for the androgen receptor, and/or which bind irreversibly to the androgen receptor. The present invention further provides methods for a) imaging of cancer in a subject, b) imaging an androgen receptor-containing tissue in a subject, c) in-vivo imaging in a subject, d) treating a subject suffering from prostate cancer, e) delaying the progression of prostate cancer in a subject suffering from prostate cancer, f) preventing the recurrence of prostate cancer in a subject suffering from prostate cancer, and g) treating the recurrence of prostate cancer in a subject suffering from prostate cancer, which comprise using the radiolabeled compounds of the present invention. The present invention further provides a method of producing the radiolabeled SARM compounds, and precursor compounds useful in the preparation of the radiolabeled SARM compounds. |
申请公布号 |
WO03074450(A3) |
申请公布日期 |
2004.08.05 |
申请号 |
WO2003US03124 |
申请日期 |
2003.02.24 |
申请人 |
THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION;DALTON, JAMES;MILLER, DUANE, D.;YIN, DONGHUA;HE, YALI |
发明人 |
DALTON, JAMES;MILLER, DUANE, D.;YIN, DONGHUA;HE, YALI |
分类号 |
A61K51/04 |
主分类号 |
A61K51/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|