METHOD OF REDUCING TOXICITY OF RETINOIDS

摘要

A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group is described. The method comprises the step of esterifying th e carboxyl group of the retinoid with a highly sterically hindered alcohol. Th e resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window.