发明名称 |
RSV GENE EXPRESSION VACCINE |
摘要 |
<p>An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA antibodies, cytotoxic T lymphocytes, and IFN-gamma production in the lung and splenocytes. A single dose of GXV induces a drastic reduction of viral titers.</p> |
申请公布号 |
EP1441762(A1) |
申请公布日期 |
2004.08.04 |
申请号 |
EP20020707777 |
申请日期 |
2002.02.12 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
MOHAPTRA, SHYAM, S.;KUMAR, MUKESH;HUANG, SHAU-KU;LEONG, KAM, W.;BEHERA, ARUNA K.;CHEN, LI-CHEN;PEREZ DE LA CRUZ, CRISTINA |
分类号 |
A61K9/62;A61K31/722;A61K39/12;A61K39/155;A61K48/00;A61P7/02;A61P11/00;A61P11/06;A61P17/02;A61P31/12;A61P37/00;A61P37/04;A61P43/00;C07K14/135;(IPC1-7):A61K39/155;A61K47/36;C12N15/00 |
主分类号 |
A61K9/62 |
代理机构 |
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代理人 |
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地址 |
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