发明名称 |
Brandykinin antagonist peptides |
摘要 |
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention further includes the intermediate compounds and additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.
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申请公布号 |
US6770741(B1) |
申请公布日期 |
2004.08.03 |
申请号 |
US19940359642 |
申请日期 |
1994.12.20 |
申请人 |
SCIOS INC. |
发明人 |
KYLE DONALD JAMES;HINER ROGER NEAL |
分类号 |
A61K38/00;C07D207/12;C07K7/18;(IPC1-7):A61K38/00;A61K38/11;C07K16/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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