| 发明名称 |
Folypolyglutamyl synthetase gene transfer to enhance antifolate drug sensitivity |
| 摘要 |
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to polyglutamylatable antifolate drugs, such as methotrexate (MTX) and edatrexate (EDX).
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| 申请公布号 |
US6770632(B1) |
申请公布日期 |
2004.08.03 |
| 申请号 |
US20000617116 |
申请日期 |
2000.07.14 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
AGHI MANISH;KRAMM CHRISTOF M.;BREAKEFIELD XANDRA O. |
| 分类号 |
A61K38/53;A61K45/06;(IPC1-7):A61K31/70;A61K48/00;C12N15/63;C12N15/86;C12N15/87 |
主分类号 |
A61K38/53 |
| 代理机构 |
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代理人 |
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| 主权项 |
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