SUBSTITUTED 4-BIPHENYL-4-HYDROXYBUTRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS

摘要

INHIBITORS FOR MATRIX METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND A PROCESS FOR USING THEM TO TREAT A VARIETY OF PHYSIOLOGICAL CONDITIONS. THE COMPOUNDS OF THE INVENTION HAVE THE GENERALIZED FORMULAIN WHICH T IS A PHARMACEUTICALLY-ACCEPTABLE SUBSTITUENT GROUP; A IS CH2, CH, OR N; G IS CH2 OR CH; AND RL IS ANY OF A VARIETY OF DISCLOSED SUBSTITUENT GROUPS. THE CLASS OF COMPOUNDS OF THE INVENTION INCLUDES RING-CONTAINING MATERIALS IN WHICH THE UNITS A AND G ARE JOINED. THE COMPOUNDS OF THE INVENTION ARE MIXTURES OFDIASTEREOMERS, OR INDIVIDUAL DIASTEREOMERS MAKING UP THESE MIXTURES.