NEW TETRACYCLIC ANALOGUES OF CAMPTOTHECINS, THEIR PREPARATION PROCESSES, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

摘要

THE INVENTION RELATES TO NEW TETRACYCLIC ANALOGUES OF CAMPTOTHECIN, THEIR PREPARATION PROCESSES, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. SAID ANALOGUES, WHICH INCLUDE IN PARTICULAR 3-HYDROXY-3(4-OXO-4,6- DIHYDROINDOLIZINO [ 1,2-B] QUINOLINE-2-YL)PENTANOIC ACID, HAVE A PAWERFUL BIOLOGICAL ACTIVITY INHIBITING TOPOISOMERASE I AND/OR TOPOISOMERASE II.