Preparing a reprogrammed diploid cell by nuclear addition where the donor nucleus is placed into an intact cell and exposed to reprogramming factors

摘要

Described is the reprogramming of a non-human adult cell nucleus to produce an embryo. The process involves: taking a donor cell or nucleus; fusing the donor nucleus with a recipient cell that has not been enucleated to produce an aneuploid cell; waiting a period of time to allow the donor nucleus to be reprogrammed; and then removing the recipient cell nucleus. This process results in a non-human embryo with a reprogrammed nucleus.