Combination therapy of angiotensin converting enzyme inhibitor and the epoxy-steroidal aldosterone antagonist eplerenone for treatment of cardiovascular disease

摘要

Combinations of an ACE inhibitor and an epoxy-steroidal aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using epoxy-steroidal-type aldosterone receptor antagonist compounds, such as eplerenone, in combination with an angiotensin converting enzyme inhibitor. This co- therapy would be particularly useful to treat congestive heart failure while avoiding or reducing aldosterone-antagonist- induced side effects such as hyperkalemia.