| 摘要 |
A compound of formula I where: R is hydrogen, (C1-7)alkyl, (C1-7)alkoxy, halogen or trifluoromethyl; R1 is hydrogen or halogen, with the proviso that R1 in 4-position is not bromine or iodine; or R and R1 may be together - CH=CH-CH=CH-; R2 is hydrogen, halogen, trifluoromethyl, (C1-7)alkoxy or cyano, with the proviso that R2 is not hydrogen, if X is -C(O)O-; R3 is independently from each other hydrogen, (C1-7)alkyl or form a cycloalkyl group; R4 is hydrogen, halogen, (C1-C7)alkyl, (C1-C7)-alkoxy, -N(R5)2, -N(R5)S(O)2-(C1-C7)-alkyl, -N(R5)C(O)R5 or is a cyclic tertiary amine selected from the group consisting of pyrrol-1-yl, imidazol-1-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4- yl, thiomorpholin-4-yl, 1-oxo-thiomorpholin-4-yl or 1,1-dioxo-thiomorpholin-4-yl, which may be substituted or unsubstituted by substituents as disclosed. R5 is independently from each other hydrogen, C3-6-cycloalkyl, benzyl, or (C1-C7)alkyl; X is -C(O)N(R5)-, -(CH2)mO-, -(CH2)mN(R5)-, -N(R5)C(O)-, -C(O)O- or -N(R5)(CH2)m; Y is -(CH2)n, -O-, -S-, -SO2-, -C(O)- or N(R5') and R5' is C3-6-cycloaklyl, benzyl or (C1-C7)-alkyl; Z is =N-, -CH= or C(Cl)= n is 0 to 4; and m is 1 or 2. A process for preparing a compound of formula I is disclosed. The use of a compound of formula I for treating various diseases is also disclosed, for example migraine, rheumatoid arthritis, asthma, pain, Alzheimer's disease, Parkinson's disease, cardiovascular change, inflammatory diseases of the gut, depression, anxiety, psychosis, motion sickness, anti-emetic.
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