| 摘要 |
<p>Compounds useful as inhibitors of PDE4 in the treatment of disease regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis and chronic obstructive pulmonary diseases, of the formula where j is 0 or 1 provided that when j is 0, n must be 2; k is 0 or 1; m is 0, 1 or 2; n is 1 or 2; W1 is -O-; or -S(=O)t-, where t is 0, 1or 2; or -N(R3)-; W2 is -O-CRARB- or is absent; Y is =C(R1a)- or -[N(O)k]- where k is 0 or 1; RA and RB are -H; -F; -CF3; -(C1-C4) alkyl; -(C3-C7) cycloalkyl; phenyl or benzyl substituted with 0 to 3 substituents R10; or RA and RB are taken together, but only in the case where m is 1, to form a spiro moiety; RC and RD have the same meaning as RA and RB except that one of them must be -H, R1 and R2 are -H; -F; -Cl; -CN; - NO2; (C1-C4) alkyl; -(C2-C4) alkynal; fluorinated (C1-C3) alkyl; -OR16; and -C(=O) NR22aR22b; R3 is -H; -(C1-C3) alkyl; phenyl; benzyl; or -OR16; R4, R5 and R6 in addition to other meanings may be taken together to form, e.g. form Q1, Q2 and Z are as defined in the application. 10 claims</p> |
