发明名称 |
IMPROVED LINKERS FOR PHARMACEUTICAL COMPOUNDS |
摘要 |
A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting compound may have the general formula M-N-O-P-Q, wherein M is the diagnostic or therapeutic moiety, N-O-P is the linker of the present invention, and Q is the targeting peptide. In another embodiment the compounds may have the formula M-N-O-P-M, wherein M is independently a diagnostic or therapeutic moiety and N-O-P is the linker of the invention. Methods for imaging or treating a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods for radiotherapy of a patient using the compounds are further provided, as are methods for preparing a radiotherapeutic agent from the compounds. |
申请公布号 |
WO2004062574(A2) |
申请公布日期 |
2004.07.29 |
申请号 |
WO2003US41656 |
申请日期 |
2003.12.24 |
申请人 |
BRACCO IMAGING S.P.A.;DE HAEN, CHRISTOPH;NUNN, ADRIAN;SWENSON, ROLF, E. |
发明人 |
DE HAEN, CHRISTOPH;NUNN, ADRIAN;SWENSON, ROLF, E. |
分类号 |
A61K51/04;A61K51/08;C07K7/23;C07K14/62 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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