| 摘要 |
A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R<1 >is hydrogen, C1-C4-alkyl, halogen, OH, or -O-C1-C4-alkyl; R<2 >is hydrogen, C1-C4-alkyl, halogen, OH, or -O-C1-C4-alkyl; R<3 >is hydrogen, C1-C4-alkyl, OH, halogen, -O-C1-C4-alkyl, -O-C1-C4-alkylene-COOH, or -O-C1-C4-alkylene-CO-O-C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
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