| 摘要 |
The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties. |
| 申请人 |
XENCOR;CHIRINO, ARTHUR, J.;DAHIYAT, BASSIL, I.;DESJARLAIS, JOHN, RUDOLPH;MARSHALL, SHANNON, ALICIA |
发明人 |
CHIRINO, ARTHUR, J.;DAHIYAT, BASSIL, I.;DESJARLAIS, JOHN, RUDOLPH;MARSHALL, SHANNON, ALICIA |
