发明名称 |
ANTIBODIES AND CYCLIC PEPTIDES WHICH BIND CEA (CARCINOEMBRYONIC ANTIGEN) AND THEIR USE AS CANCER THERAPEUTICS |
摘要 |
The present invention relates to differentiation and tumorigenicity. The present invention more particularly relates to ligands which target CEA and CEACAM6 such that the adhesion, differentiation-Inhibitory activities and tumorigenic effects of Ig superfamily members, CEA and CEACAM6, can be reduced or blocked. More particularly, the present invention relates to CEA-binding agents which reverse CEA-mediated tumorigenic effects by declustering CEA and CEACAM6. In one embodiment the invention relates to methods of reducing, preventing or reversing a CEA-mediated tumorigenic effect comprising a use of a CEA-mediated tumorigenic effect reducing CEA-declustering agent. In one embodiment, the invention relates to compositions and use thereof for reversing CEA-mediated tumorigenic effects on human cancer cells and uses thereof. In particular, the application relates to a monovalent CEA binding agent which interfereswith a CEA interaction responsible for a CEA-mediated tumorigenic effects, thereby minimizing or reversing same. |
申请公布号 |
WO2004031238(A3) |
申请公布日期 |
2004.07.29 |
申请号 |
WO2003CA01533 |
申请日期 |
2003.10.03 |
申请人 |
MCGILL UNIVERISTY;STANNERS, CLIFFORD, P.;ILANTZIS, CHRISTIAN |
发明人 |
STANNERS, CLIFFORD, P.;ILANTZIS, CHRISTIAN |
分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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