发明名称 |
LIPID A AND OTHER CARBOHYDRATE LIGAND ANALOGS |
摘要 |
The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc. |
申请公布号 |
WO03094850(A3) |
申请公布日期 |
2004.07.29 |
申请号 |
WO2003US14633 |
申请日期 |
2003.05.09 |
申请人 |
BIOMIRA, INC.;MCINNIS, PATRICIA;JIANG, ZI-HUA;KOGANTY, R., RAO;BUDZYNSKI, WLADYSLAW |
发明人 |
JIANG, ZI-HUA;KOGANTY, R., RAO;BUDZYNSKI, WLADYSLAW |
分类号 |
A61K9/127;A61K31/6615;A61K31/70;A61K31/7032;A61K39/39;A61P31/04;A61P31/12;A61P35/00;A61P37/04;A61P43/00;C07F9/09;C07H15/04;C07H15/12 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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