| 发明名称 |
UREA DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS |
| 摘要 |
<p>The present invention provides compositions and their use in the treatment of inflammatory diseases caused by T-cell proliferation such as sepsis, inflammatory bowel diseases, autoimmune encephalomyelitis, or lupus. The compositions comprise disubstituted ureas of Formulas I, II, III or IV: Formula I: R<1>-NH-CO-NH-Q-R<2>, Formula (II): Et-NH-CO-NH-Q-R<2>, Formula (III): Et-NH-CO-NH-(CH2)3-NR<6>R<7>, Formula (IV): Me2N(CH2)3-NH-CO-NH-Q-R<2>.</p> |
| 申请公布号 |
WO2004063181(A1) |
申请公布日期 |
2004.07.29 |
| 申请号 |
WO2003US41470 |
申请日期 |
2003.12.23 |
| 申请人 |
GENZYME CORPORATION |
发明人 |
STAVESKI, MARK, M.;MILLER, ROBERT;NAHILL, SHARON, R. |
| 分类号 |
C07C275/06;A61P29/00;A61P31/00;A61P37/00;C07C275/12;C07C275/14;C07C275/16;C07C275/20;C07C275/24;C07C275/26;C07C275/34;C07C275/42;C07C275/64;C07C311/47;C07D211/26;C07D211/32;C07D211/58;C07D213/74;C07D217/04;C07D217/22;C07D231/40;C07D235/30;C07D241/20;C07D249/08;C07D257/06;C07D277/58;C07D277/82;C07D285/00;C07D285/01;C07D295/13;C07D295/205;C07D295/215;C07D307/14;C07D307/52;C07D333/20;C07D333/58;C07D487/04;(IPC1-7):C07D307/38;C07C275/08;A61K31/341;A61K31/17 |
主分类号 |
C07C275/06 |
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