发明名称 |
HETEROCYCLIC PPAR MODULATORS |
摘要 |
<p>The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) Z1 and Z2 are each independently selected from the group consisting of N, O, and C with the proviso that at least one of Z1 and Z2 is N; (f) Z3 is selected from the group consisting of N, O, and C. (g) R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C4 alkylenyl and halo; (h) R9 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkylenyl, halo, aryl- C0-C4 alkyl, heteroaryl, C1-C6 allyl, and OR29.</p> |
申请公布号 |
WO2004063166(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
WO2003US39119 |
申请日期 |
2003.12.31 |
申请人 |
ELI LILLY AND COMPANY;CONNER, SCOTT, EUGENE;MA, TIANWEI;MANTLO, NATHAN, BRYAN;MAYHUGH, DANIEL, RAY;SCHKERYANTZ, JEFFREY, MICHAEL;WARSHAWSKY, ALAN, M.;ZHU, GUOXIN |
发明人 |
CONNER, SCOTT, EUGENE;MA, TIANWEI;MANTLO, NATHAN, BRYAN;MAYHUGH, DANIEL, RAY;SCHKERYANTZ, JEFFREY, MICHAEL;WARSHAWSKY, ALAN, M.;ZHU, GUOXIN |
分类号 |
A61P3/00;A61P9/00;C07D231/12;C07D233/20;C07D233/22;C07D253/04;C07D261/08;(IPC1-7):C07D231/12;A61K31/415 |
主分类号 |
A61P3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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