发明名称 |
PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF |
摘要 |
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium sa lt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.
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申请公布号 |
CA2512980(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
CA20042512980 |
申请日期 |
2004.01.13 |
申请人 |
ATHEROGENICS, INC. |
发明人 |
SIKORSKI, JAMES A.;WEINGARTEN, M. DAVID |
分类号 |
C07C319/20;C07C323/20;(IPC1-7):C07C9/00 |
主分类号 |
C07C319/20 |
代理机构 |
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代理人 |
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地址 |
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