发明名称 |
Methods for the identification of inhibitors of Trehalose-6-Phosphate Synthase as antibiotics |
摘要 |
The present inventors have discovered that Trehalose-6-Phosphate Synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of Trehalose-6-Phosphate Synthase gene expression in fungi results in reduced pathogenicity (i.e. smaller, non-viable lesions). Thus, Trehalose-6-Phosphate Synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit Trehalose-6-Phosphate Synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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申请公布号 |
US2004146960(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
US20030703292 |
申请日期 |
2003.11.07 |
申请人 |
DARVEAUX BLAISE;MAHANTY SANJOY;HEINIGER RYAN;COVINGTON AMY;PAN HUAQIN;TARPEY REX;SHUSTER JEFFREY;TANZER MATTHEW M.;HAMER LISBETH;ADACHI KIICHI;DEZWAAN TODD;LO SZE-CHUNG;MONTENEGRO-CHAMORRO MARIA VICTORIA;FRANK SHERYL |
发明人 |
DARVEAUX BLAISE;MAHANTY SANJOY;HEINIGER RYAN;COVINGTON AMY;PAN HUAQIN;TARPEY REX;SHUSTER JEFFREY;TANZER MATTHEW M.;HAMER LISBETH;ADACHI KIICHI;DEZWAAN TODD;LO SZE-CHUNG;MONTENEGRO-CHAMORRO MARIA VICTORIA;FRANK SHERYL |
分类号 |
C12N9/10;C12Q1/18;C12Q1/48;(IPC1-7):C12Q1/48 |
主分类号 |
C12N9/10 |
代理机构 |
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