NOVEL PROCESS FOR PREPARING A 5-HYDROXY-3-OXO-HEXANOIC ACID DERIVATIVE

摘要

The present invention is related to a novel process for preparing an optical ly active 5-hydroxy-3-oxo-hexanoic acid derivative or its tautomer which is useful intermediate for preparing statins such as atorvastatin and rosuvastatin. Blaise reaction of (S)-4-halo-3 -hydroxybutyronitrile with - haloacetate is utilized as a key reaction to provide the product with minima l formation of side products and in good yield.