发明名称 |
Compounds that modulate the activity of PTP-1B and TC-PTP |
摘要 |
The present invention relates to a new and improved method for treating diabetes and or its associated complications by modulating the activity of protein tryosin phosphatase 1B ("PTP-1B"). The inventive compounds modulate the activity PTP-1B by binding to a novel binding site referred herein as the PTP-1B exosite that is distal to the active site of PTP-1B. The present invention also relates to a new and improved method of treating immune system disorders by modulating the activity of T-cell protein tyrosine phosphatase ("TC-PTP"). The inventive compound modulate the activity of TC-PTP by binding to a novel binding site referred herein as the TC-PTP exosite that is distal to the active site of PTP-1B.
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申请公布号 |
US2004147596(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
US20040788564 |
申请日期 |
2004.02.27 |
申请人 |
BARR KENNETH;FAHR BRUCE;HANSEN STIG;WIESMANN CHRISTIAN |
发明人 |
BARR KENNETH;FAHR BRUCE;HANSEN STIG;WIESMANN CHRISTIAN |
分类号 |
C12N15/09;A61K31/343;A61K31/635;A61K45/00;A61P3/04;A61P3/10;A61P9/00;A61P13/12;A61P27/02;A61P43/00;C07D307/80;C07D405/12;C07D417/12;C12Q1/42;(IPC1-7):A61K31/545 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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