发明名称 |
NOVEL PROTEINS WITH ALTERED IMMUNOGENICITY |
摘要 |
The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties. |
申请公布号 |
CA2512693(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
CA20042512693 |
申请日期 |
2004.01.08 |
申请人 |
XENCOR, INC. |
发明人 |
MARSHALL, SHANNON ALICIA;DESJARLAIS, JOHN RUDOLPH;DAHIYAT, BASSIL I.;CHIRINO, ARTHUR J. |
分类号 |
A61K38/08;A61K38/10;C07K7/06;C07K7/08;C12N15/11;G06F17/50;G06F19/00;G06F19/16;(IPC1-7):C12N15/11 |
主分类号 |
A61K38/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|