发明名称 |
Antibodies specific for a cell surface molecule mediating cell adhesion and signal transmission, cells secreting such antibodies, and methods of making and using such antibodies |
摘要 |
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have been isolated, identified, and analyzed for their functions. The cell surface molecules are expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes, and induce cell adhesion. Antibodies against the cell surface molecules significantly ameliorate pathological conditions of autoimmune diseases and allergic diseases.
|
申请公布号 |
US2004146506(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
US20030704030 |
申请日期 |
2003.11.07 |
申请人 |
JAPAN TOBACCO INC., A JAPANESE CORPORATION |
发明人 |
TAMATANI TAKUYA;TEZUKA KATSUNARI |
分类号 |
A01K67/027;A61K38/00;A61K39/395;A61P29/00;A61P37/00;A61P37/02;C07K14/47;C07K14/705;C07K16/18;C07K16/28;C07K19/00;C12N1/21;C12N5/00;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/19;C12R1/91;(IPC1-7):A61K39/395;C07K16/44 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|