发明名称 |
PROCESS FOR THE PREPARATION OF 1,2-DICHLOROETHANE FREE CRYSTALS OF ZONISAMIDE AND THE HIGHLY PURE CRYSTALS OF ZONISAMIDE |
摘要 |
<p>A process for the preparation of crystals of zonisamide containing residual 1,2-dichloroethane of not more than 5 ppm, by adding an aqueous C2-4 alcohol to crystals of zonisamide containing residual 1,2-dichloro-ethane of more than 5 ppm, removing the 1,2-dichloroethane by azeotropic distillation, followed by collecting the precipitated crystals from the residual mixture, and the highly pure crystals of zonisamide containing residual 1,2-dichloroethane of not more than 5 ppm, which is useful as an antiepileptic agent.</p> |
申请公布号 |
WO2004063174(A1) |
申请公布日期 |
2004.07.29 |
申请号 |
WO2003JP09530 |
申请日期 |
2003.07.28 |
申请人 |
DAINIPPON PHARMACEUTICAL CO., LTD. |
发明人 |
UENO, YOSHIKAZU;KIMURA, YASUJIRO |
分类号 |
A61P25/08;C07D261/20;(IPC1-7):C07D261/20 |
主分类号 |
A61P25/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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