DRY DISPERSIONS

摘要

A process for the preparation of a solid pharmaceutically particulate material by spraydrying an aqueous dispersion comprising an active substance together with a lipid material and one or more pharmaceutically acceptable carriers. The particulate material obtained by the process has suitable properties with respect to non-cohesiveness, density and particle size, which enables it to be further processed into a solid dosage form such as, e.g. tablets. By use of the process it is possible to incorporate a relatively high amount of a lipid material into a particulate material, which makes the process especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance that has a relatively low aqueous solubility, has a relatively low bioavailability and/or is subject to chemical decomposition. By employment of the process according to the invention pharmaceutical compositions can be prepared that have improved physico-chemical properties e.g. with respect to release of the active substance from the composition as evidenced by in vitro dissolution test and/or improved pharmacological properties e.g. with respect to bioavailability and efficacy.