| 摘要 |
Receptor blocker (antagonist) drugs which suppress the binding of the D4 cla ss of leukotriene molecules to leukotriene receptors can reduce the frequency a nd severity of recurrent primary headaches, including migraine and cluster headaches. Various LTD4 receptor blockers are commercially available, including montelukast and zafirlukast. In the past, these drugs have been us ed to treat asthma. During human clinical trials on asthma patients, headaches were one of the most commonly reported side effects of each of those two drugs; therefore, they apparently were never tested as agents which might prevent or reduce migraine or cluster headaches. However, it has been shown that in at least some patients who suffer from acute recurrent migraines, LT D4 receptor blockers can greatly reduce the frequency, duration, and/or severit y of their headaches, when taken chronically on a daily basis. Tests also indicate that LTD4 receptor blockers can effectively treat onset of acute migraine or cluster headaches, and can also be combined with a triptan drug to achieve a synergistic effect against acute headaches. |
