发明名称 |
Sustained release preparation comprising one or more antibiotics and polymers |
摘要 |
<p>Incorporation of an aminoglycoside, lincosamide, tetracycline, quinolone or beta -lactam antibiotic in a homogeneous mixture of a hydrophobic polymethacrylate, polyacrylate and/or poly(methacrylate-co-acrylate) polymer and a hydrophilic polyether polymer provides continuous release of the antibiotic. An antibiotic-polymer composite comprises a suspension of one or more aminoglycoside, lincosamide, tetracycline, quinolone or beta -lactam antibiotics and optionally one or more organic additives in a homogeneous polymer mixture of one or more hydrophobic polymethacrylate, polyacrylate and/or poly(methacrylate-co-acrylate) polymers and one or more hydrophilic polyether polymers. The aminoglycoside, lincosamide and tetracycline antibiotics have poor water-solubility or may be readily soluble in water, the quinolone antibiotics have a poor solubility in water and the beta -lactam antibiotics may be readily soluble in water.</p> |
申请公布号 |
EP1243259(B1) |
申请公布日期 |
2004.07.28 |
申请号 |
EP20020004978 |
申请日期 |
2002.03.06 |
申请人 |
HERAEUS KULZER GMBH & CO.KG |
发明人 |
VOGT, SEBASTIAN F., DR.;SCHNABELRAUCH, MATTHIAS, DR.;KUEHN, KLAUS-DIETER, DR. |
分类号 |
A61L31/00;A61K9/00;A61K9/70;A61K31/00;A61K31/65;A61K31/70;A61K31/7036;A61K31/726;A61K47/10;A61K47/32;A61K47/48;A61L24/00;A61L27/00;A61L27/34;A61L27/44;A61L27/54;A61L29/00;A61L29/08;A61L29/12;A61L29/16;A61L31/10;A61L31/16;A61P31/00;(IPC1-7):A61K9/70;A61K31/703 |
主分类号 |
A61L31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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