| 摘要 |
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the other one is CH2, O or S; Z is N, C, CH or COH; Ar is an optionally substituted aryl group; R<1 >is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, acyl, thioacyl, alkylsulfonyl, trifluoromethylsulfonyl, arylsulfonyl, a group R<9>VCO- where V is O or S and R<9 >is alkyl or aryl, or a group R<10>R<11>NCO- or R<10>R<11>NCS- wherein R<10 >and R<11 >are hydrogen, alkyl or aryl, or R<10 >and R<11 >are linked to form a ring; R<2 >is hydrogen, alkyl, cykcloalkyl or cycloalkylalkyl; or R<1 >and R<2 >are linked to form a ring; R<3>-R<5 >are hydrogen, halogen, alkyl, alkylcarbonyl, phenylcarbonyl, alkoxy, alkylthio, hydroxy, alkylsulfonyl, cyano, trifluoromethyl, cycloalkyl, cycloalkylalkyl or nitro; R<6 >and R<7 >are hydrogen or alkyl or they are linked to constitute 3-7 membered ring; R<8 >is hydrogen or alkyl; have effects at central serotonergic receptors and are therefore useful in the treatment of certain psychic and neurologic disorders.
|
